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Spermidine Supplements: Longevity in a Bottle or a Fraud?

Imagine yourself mingling at a hip Silicon Valley party, and instead of pretentious craft beers and soylent guests are sipping on... spermidine smoothies? Well, in everyone's quest for eternal youth today it doesn’t seem like a far-fetched reality. 

Spermidine, a compound found in foods like aged cheese and legumes, is making some serious waves in the supplement world. But is it the fountain of youth in a capsule, or just another overhyped fad? And can you turn it into your own 1 billion dollars business idea? 

Disclaimer: I discovered this trend using Exploding topics (I am an affiliate and a long-time fan of this tool), which has become my go-to resource for uncovering under-the-radar opportunities. While the tool doesn’t provide the research that comes with my newsletter, if you're into finding even more trends in all the fields, this tool is definitely worth a look. 

Table of Contents

Current state and financial opportunities

The spermidine supplement market is no small potatoes. According to Valuates Reports, it was valued at $194 million in 2023 and is projected to hit $331.1 million by 2030, growing at a CAGR of 7.8%. 

But here's where it gets interesting. The broader anti-aging market? Is at a $62 billion valuation, expected to balloon to $93 billion by 2027. Spermidine supplements definitely fit into this anti-aging ocean. 

With companies selling hundreds and thousands of bottles of Spermidine supplements per month, there’s surely an area for growth and more opportunities. 

Spermidine supplements: key players

While the spermidine supplement market is buzzing, the inconvenient truth is that there's a glaring lack of research proving the efficacy of these supplements. In fact, there was a study from Dr. Richard Miller's mentioned in this video, and it suggests that many marketing claims for these supplements have been extrapolated from research that's not directly related to the supplements themselves.

Despite these red flags, several companies are making waves in the space:

Longevity Labs present themselves as research-focused, but they've only conducted 10+ clinical trials across their entire product range (and it’s way more than spermidine). That's a start, but it's hardly enough to definitively prove the efficacy of their supplements. Not to mention that the results on those trials don't seem to be easily found on the company's website. On top of it some of the people listed on the company's advisory board lately have been discredited by the medical community.

Then there’s Double Wood Supplements, a company that according to Crunchbase was acquired by Boyne Capital Partners in 2021. Interestingly enough, my husband is a big fan of supplements and only in a few couple of years I am seeing an excessive number of Double Wood bottles on his supplements shelf. Which makes me believe that after acquisition the marketing became way stronger with the company. But since its new owner, Boyne Capital Partners, has zero expertise in pharmaceuticals or healthcare (according to Crunchbase data) niche I am quite torn on by the quality of the research and trial backing this product, and subscequently it raises fair questions about their ability to address the fundamental issues with spermidine supplements.

Youth and Earth is running a Shopify store with an aggressive affiliate program (giving away about 30% of product cost in discounts to both sides of affiliate trades — partners and buyers). While their estimated revenue of $1M to $10M in anti-aging supplements is impressive, their approach seems more focused on marketing than on solving the core problem of supplement efficacy.

Renue By Science, another player in spermedine supplements niche is making quite a difference by publishing product testing results on their website. However, these tests mostly focus on raw material quality and stability rather than the crucial question of whether the supplements actually raise spermidine levels or provide the claimed benefits. (But that’s a good start compared to all the competitors). 

To be clear, I'm not saying these companies' supplements don't work. But based on the information available on their websites, none of them appear to be directly addressing the elephant in the room: the lack of evidence for spermidine supplement efficacy.

This situation presents a golden opportunity for entrepreneurial founders. There's a clear gap in the market for a company that can develop a spermidine supplement with proven efficacy, backed by clinical trials specifically designed to test the supplement itself, not just extrapolate from dietary studies. The first company to crack this nut - to create a spermidine supplement that demonstrably raises blood spermidine levels and provides measurable health benefits - could potentially dominate this growing market.

In short, the field is wide open for a science-first approach that prioritizes efficacy over marketing hype. Any takers?

Benefits and drawbacks

Spermidine supplements aren't all sunshine and rainbows. Let's break it down:

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